Well, there is still a difference — at least, in my humble opinion — between a hybrid created from two or more sapient species, and a hybrid created from a sapient species and a non-sapient species.
Self-modifying computer code does exist. Among other things, this ability of a computer program to modify its own code is the basis of artificial intelligence, but at a less ambitious scale, it is also how a so-called worm works. It modifies its own code in order to avoid detection. And of course, it doesn't "know" anything, because it's just a very cleverly designed algorithm.
As for whether humans know what they're doing, I think we've seen ample evidence already all over the pages of history that they don't (
*), and from the looks of what appears in the mainstream media news every day, the vast majority of them probably never will.
(*) "My God, what have I done?"
(Robert Oppenheimer, upon witnessing the detonation of the first nuclear bomb)