The show's narrator states that a 7 foot tall green lizard like humanoid has been witnessed by dozens people over the past few decades near Scape Ore Swamp in South Carolina.
This show briefly recounts one incident that was covered in a previous Monsters and Mysteries show. A man who was changing a flat tire at night near the swamp was approached by an aggressive creature. The man quickly jumped in his car and proceeded to speed off however the creature managed to jump on the roof of his car. The man got a good look at the creature and noticed it's reptilian features and 3-clawed hands. He managed to shake the creature off the car and then reported the incident to the police.
The show then goes on to talk about a more recent daytime sighting, where a pilot was going down a run-way, preparing to take-off when along side the clearing a tall greenish-brown creature stepped out into the field. The creature looked directly at the plane and the man could see its face which he said looked kind of like a monkey, but had a longer face than a monkey. He could not tell if it had skin or scales but looked like some of both an animal and a human.
They then go on to talk about Native American stories from that area of "Men with Tails" that were fish eaters and live in swamps.
They then cover an account that happened in the Great Smokey Mountains. A teen going through the area had bedded down in the forest and was approached in the middle of the night by an aggressive creature. He got a good look at the creature which he said had yellow eyes, was humanoid but very reptile in appearance, with ridges on it's head and talon like hands. He managed to escape, walked for hours, then find a road where he was picked up by a Native American driving a truck. The driver asked what had happened to him as he looked terrible. He told the driver of his encounter and the man said, "Your lucky you only ran into the one."
Please note this episode covers three topics, first the Reptile Man, then the Succubus and lastly the Napa Valley Creatures. The other two topics are interesting also.