Actually, I found Roger Penrose the one who was probably the most condescending toward Michio Kaku, although I will add that I do not believe he meant
it that way. It's just how his brain works, and the moderator of the debate was basically setting Roger up for certain replies that evoked laughter from the audience.
Sabine was being very down-to-earth about it all, in my opinion. But she and
Roger have a right to disagree with Michio. As Roger pointed out, there are
issues with quantum mechanics and the Copenhagen interpretation of the collapse of the wave function — that was Schrödinger's whole point with the famous thought experiment of the cat in the box — and they do have a point that string theory has so far not really provided any substantial evidence, given that it's a purely theoretical science.
I think it may probably still be a long time before anyone comes up with a genuine (and verifiable) Theory Of Everything™
, even if only because we are limited as humans in what we can test. And that was Sabine's point.