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Thread: Light-activated bio-glue that moves with beating heart has potential for human use

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    Administrator Aragorn's Avatar
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    Lightbulb Light-activated bio-glue that moves with beating heart has potential for human use

    Source: CNN




    A diagram of how researchers used adhesive hemostatic hydrogel for the repair of arterial and heart bleeds in pigs.



    Uncontrolled bleeding during surgery can cause death. What if, instead of slow surgical stitching, you could rapidly glue a wound together?

    A new "bio-glue" -- an experimental adhesive gel that is activated by a flash of light -- has been proven to stop high pressure bleeding in the hearts of pigs. Additional research confirming the safety of this product is needed before experiments can begin in humans, according to the authors of a study published Wednesday in the journal Nature Communications.

    Around the globe, more than 234 million surgeries are performed each year, the World Health Organization estimates.

    Surgical suturing is especially difficult when dealing with diseased, damaged or small blood vessels, according to the study authors. Existing surgical products, such as Fibrin Glue and Surgiflo, have been effective in stopping bleeding during surgeries, but they take minutes to set and in some cases require additional stitching.





    Numerous attempts have been made to create improved and swifter-acting surgical adhesives, but few nontoxic materials can meet the criteria of holding fast on wet tissues while resisting pressure and the movement of a beating heart.

    A team of researchers from Zhejiang University School of Medicine in Hangzhou, China, accepted the challenge. Inspired by the matrix composition of human connective tissues, they created a gel composed of a network of proteins and other molecules. The product, which requires ultraviolet light to activate, can adhere within seconds and then bond to wet biological tissue surfaces.

    In early experiments, the research team showed that their bio-glue could seal wounds to pig livers. Next, they demonstrated that wounds and punctures of hearts -- among the most difficult of surgical challenges -- could also be sealed using only the bio-glue, no stitches.

    In pigs, the bio-glue sealed a punctured carotid artery, a major blood vessel in the neck, in less than a minute and also filled holes in the cardiac wall. The Chinese researchers monitored their post-surgical pigs for a two-week recovery period and saw natural healing with no abnormalities or unusual inflammation.

    The surgical repairs can withstand a systolic blood pressure reading of up to 290 millimeters of mercury, or mmHg, which is "significantly higher" than systolic readings seen by most doctors (the usual range is between 60 and 160), the study authors noted.

    "Most importantly, the hydrogel can stop high-pressure bleeding from pig carotid arteries with 4~ 5 mm-long incision wounds and from pig hearts with 6 mm diameter cardiac penetration holes."

    Based on these early experiments, the bio-glue shows promise for use in human surgeries and to stop emergency bleeding, the authors concluded.


    Source: CNN
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    Senior Member NotAPretender's Avatar
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    yeah, another great one...
    "We are one thought away from changing the world!"

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    Senior Member Aianawa's Avatar
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    Mmmm unsure.

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    Administrator Aragorn's Avatar
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    Quote Originally posted by Aianawa View Post
    Mmmm unsure.
    Would you care to elaborate?
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    Almost reminds me of 5 Second Fix but for flesh and bits
    Oh, I may be on the side of the angels. But don't think for one second that I am one of them.

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    Senior Member Aianawa's Avatar
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    Very unsure, they hoaxing ?.


    Quote Originally posted by Aragorn View Post
    Would you care to elaborate?

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    Administrator Aragorn's Avatar
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    Quote Originally posted by Aianawa View Post
    Very unsure, they hoaxing ?.
    That would be quite a stretch. For that matter, dentists also use a filler material that hardens by exposure to a powerful blue light. Light-curing is quite well-known already in various medical and industrial branches.
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    Senior Member Aianawa's Avatar
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    Some facets of data I find difficult to get into, ta

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    Quote Originally posted by Aianawa View Post
    Some facets of data I find difficult to get into, ta
    Um, you didn't find it so hard to believe in the QAnon hoax, though...
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    Oh, I may be on the side of the angels. But don't think for one second that I am one of them.

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    Senior Member Aianawa's Avatar
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    What does emotionalllly advanced humanity look like asked the boulder, because mum told me we will know when as we will feel them, sensing humanity now I do not have as many Q's said mummy/Earth.

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