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Born in Budapest, Hungary in 1944, Maté is a Jewish survivor of the Holocaust. His maternal grandparents were killed in Auschwitz when he was five months old. His aunt disappeared during the war, and his father endured forced labour at the hands of the Nazis. He emigrated to Canada with his family in 1956. He was a student radical during the Vietnam War era in the late 1960s and graduated with a B.A. from the University of British Columbia in Vancouver.
He has a background in family practice and a special interest in childhood development and trauma, and in their potential lifelong impacts on physical and mental health, including on autoimmune disease, cancer, ADHD, addictions, and a wide range of other conditions.