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View Full Version : Science found a gene introduced to the gene pool 37,000 years ago



DeeZe
19th May 2015, 19:14
http://www.ncbi.nlm.nih.gov/pubmed/16151009

Science. 2005 Sep 9;309(5741):1717-20.

Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans.

Abstract

The gene Microcephalin (MCPH1) regulates brain size and has evolved under strong positive selection in the human evolutionary lineage. We show that one genetic variant of Microcephalin in modern humans, which arose approximately 37,000 years ago, increased in frequency too rapidly to be compatible with neutral drift. This indicates that it has spread under strong positive selection, although the exact nature of the selection is unknown. The finding that an important brain gene has continued to evolve adaptively in anatomically modern humans suggests the ongoing evolutionary plasticity of the human brain. It also makes Microcephalin an attractive candidate locus for studying the genetics of human variation in brain-related phenotypes.